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|Title:||An unnatural amino acid that mimics phosphotyrosine|
|Citation:||Ge, J., Wu, H., Yao, S.Q. (2010). An unnatural amino acid that mimics phosphotyrosine. Chemical Communications 46 (17) : 2980-2982. ScholarBank@NUS Repository. https://doi.org/10.1039/c000283f|
|Abstract:||By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (protein-protein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and cell-proliferation experiments. © The Royal Society of Chemistry 2010.|
|Source Title:||Chemical Communications|
|Appears in Collections:||Staff Publications|
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