Please use this identifier to cite or link to this item: https://doi.org/10.1039/c000283f
Title: An unnatural amino acid that mimics phosphotyrosine
Authors: Ge, J.
Wu, H. 
Yao, S.Q. 
Issue Date: 2010
Citation: Ge, J., Wu, H., Yao, S.Q. (2010). An unnatural amino acid that mimics phosphotyrosine. Chemical Communications 46 (17) : 2980-2982. ScholarBank@NUS Repository. https://doi.org/10.1039/c000283f
Abstract: By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (protein-protein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and cell-proliferation experiments. © The Royal Society of Chemistry 2010.
Source Title: Chemical Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/75570
ISSN: 13597345
DOI: 10.1039/c000283f
Appears in Collections:Staff Publications

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