Please use this identifier to cite or link to this item:
https://doi.org/10.1021/jo202221c
DC Field | Value | |
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dc.title | An enantioselective approach toward 3,4-dihydroisocoumarin through the bromocyclization of styrene-type carboxylic acids | |
dc.contributor.author | Chen, J. | |
dc.contributor.author | Zhou, L. | |
dc.contributor.author | Tan, C.K. | |
dc.contributor.author | Yeung, Y.-Y. | |
dc.date.accessioned | 2014-06-23T05:31:52Z | |
dc.date.available | 2014-06-23T05:31:52Z | |
dc.date.issued | 2012-01-20 | |
dc.identifier.citation | Chen, J., Zhou, L., Tan, C.K., Yeung, Y.-Y. (2012-01-20). An enantioselective approach toward 3,4-dihydroisocoumarin through the bromocyclization of styrene-type carboxylic acids. Journal of Organic Chemistry 77 (2) : 999-1009. ScholarBank@NUS Repository. https://doi.org/10.1021/jo202221c | |
dc.identifier.issn | 00223263 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/75562 | |
dc.description.abstract | A facile and enantioselective approach toward 3,4-dihydroisocoumarin was developed. The method involved an amino-thiocarbamate catalyzed enantioselective bromocyclization of styrene-type carboxylic acids, yielding 3-bromo-3,4-dihydroisocoumarins with good yields and ee's. 3-Bromo-3,4- dihydroisocoumarins are versatile building blocks for various dihydroisocoumarin derivatives in which the Br group can readily be modified to achieve biologically important 4-O-type and 4-N-type 3,4-dihydroisocoumarin systems. In addition, studies indicated that, by refining some parameters, the synthetically useful 5-exo phthalide products could be achieved with good yields and ee's. © 2011 American Chemical Society. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/jo202221c | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1021/jo202221c | |
dc.description.sourcetitle | Journal of Organic Chemistry | |
dc.description.volume | 77 | |
dc.description.issue | 2 | |
dc.description.page | 999-1009 | |
dc.description.coden | JOCEA | |
dc.identifier.isiut | 000299238400021 | |
Appears in Collections: | Staff Publications |
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