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|Title:||Aldol reaction under solvent-free conditions: Highly stereoselective synthesis of 1,3-amino alcohols|
|Authors:||Loh, T.-P. |
|Citation:||Loh, T.-P.,Huang, J.-M.,Goh, S.-H.,Vittal, J.J. (2000-05-04). Aldol reaction under solvent-free conditions: Highly stereoselective synthesis of 1,3-amino alcohols. Organic Letters 2 (9) : 1291-1294. ScholarBank@NUS Repository.|
|Abstract:||(formula presented) A method for the highly stereoselective synthesis of 1,3-amino alcohols based on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto ester (R,S)-1 under solvent-free conditions has been developed. The high selectivity observed can be explained on the basis of the shielding of one face by a remote substituent.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
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