Please use this identifier to cite or link to this item: https://doi.org/10.1002/cbic.200500340
Title: Activity-based fingerprinting of proteases
Authors: Srinivasan, R.
Huang, X.
Ng, S.L.
Yao, S.Q. 
Keywords: Activity-based profiling
Enzymes
Microarrays
Proteases
Proteomics
Issue Date: Jan-2006
Citation: Srinivasan, R., Huang, X., Ng, S.L., Yao, S.Q. (2006-01). Activity-based fingerprinting of proteases. ChemBioChem 7 (1) : 32-36. ScholarBank@NUS Repository. https://doi.org/10.1002/cbic.200500340
Abstract: Not inhibited. We have successfully synthesized and tested a panel of activity-based small-molecule probes that target different classes of proteases on the basis of their enzymatic activities and substrate specificities rather than their inhibition. We have demonstrated that these probes are useful for generating unique substrate fingerprint profiles of proteases in gel-based proteomic experiments. Preliminary results indicate that they might be equally amenable for microarray-based enzyme profiling experiments. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
Source Title: ChemBioChem
URI: http://scholarbank.nus.edu.sg/handle/10635/75520
ISSN: 14394227
DOI: 10.1002/cbic.200500340
Appears in Collections:Staff Publications

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