Please use this identifier to cite or link to this item:
|Title:||Acetal-functionalized RAPTA complexes for conjugation and labeling|
|Citation:||Tan, Y.Q., Dyson, P.J., Ang, W.H. (2011-11-14). Acetal-functionalized RAPTA complexes for conjugation and labeling. Organometallics 30 (21) : 5965-5971. ScholarBank@NUS Repository. https://doi.org/10.1021/om200783r|
|Abstract:||Ruthenium-arene complexes bearing the 1,3,5-triaza-7-phosphatricyclo-[3.3. 1.1]decane ligand, namely, RAPTA compounds, are widely investigated as potential antimetastatic agents for cancer therapy. Although much evidence points toward covalent binding with essential protein biomolecules as the key determinant of their activity, the exact biological targets of RAPTA remain elusive. To address this current gap in understanding, RAPTA compounds derivatized with acetal groups via a pendant chain to the arene ligand were developed as a functional probe for selective postlabeling and tagging of covalent RAPTA adducts in cancer cells. © 2011 American Chemical Society.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 5, 2018
WEB OF SCIENCETM
checked on Nov 27, 2018
checked on Nov 24, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.