Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2sc20248d
Title: A concise, efficient synthesis of sugar-based benzothiazoles through chemoselective intramolecular C-S coupling
Authors: Shen, C.
Xia, H.
Yan, H.
Chen, X.
Ranjit, S.
Xie, X.
Tan, D.
Lee, R.
Yang, Y.
Xing, B.
Huang, K.-W.
Zhang, P.
Liu, X. 
Issue Date: Jul-2012
Citation: Shen, C., Xia, H., Yan, H., Chen, X., Ranjit, S., Xie, X., Tan, D., Lee, R., Yang, Y., Xing, B., Huang, K.-W., Zhang, P., Liu, X. (2012-07). A concise, efficient synthesis of sugar-based benzothiazoles through chemoselective intramolecular C-S coupling. Chemical Science 3 (7) : 2388-2393. ScholarBank@NUS Repository. https://doi.org/10.1039/c2sc20248d
Abstract: Sugar-based benzothiazoles are a new class of molecules promising for many biological applications. Here, we have synthesized a wide range of sugar-based benzothiazoles from readily accessible glycosyl thioureas by chemoselective, palladium-catalyzed C-S coupling reactions. Corroborated by theoretical calculations, a mechanistic investigation indicates that the coordination to the palladium by a pivaloyl carbonyl group and the presence of intramolecular hydrogen bonding play important roles in the efficiency and chemoselectivity of reaction. These fluorescent glycoconjugates can be observed to readily enter mammalian tumor cells and exhibit potential in vitro antitumor activity. This journal is © The Royal Society of Chemistry 2012.
Source Title: Chemical Science
URI: http://scholarbank.nus.edu.sg/handle/10635/75405
ISSN: 20416520
DOI: 10.1039/c2sc20248d
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