Please use this identifier to cite or link to this item: https://doi.org/10.1039/c0cc03738a
Title: "Click" synthesis of small molecule-peptide conjugates for organelle-specific delivery and inhibition of lysosomal cysteine proteases
Authors: Loh, Y.
Shi, H.
Hu, M.
Yao, S.Q. 
Issue Date: 28-Nov-2010
Citation: Loh, Y., Shi, H., Hu, M., Yao, S.Q. (2010-11-28). "Click" synthesis of small molecule-peptide conjugates for organelle-specific delivery and inhibition of lysosomal cysteine proteases. Chemical Communications 46 (44) : 8407-8409. ScholarBank@NUS Repository. https://doi.org/10.1039/c0cc03738a
Abstract: A click chemistry approach for the synthesis of small molecule inhibitor-peptide conjugates to achieve organelle-specific delivery has been developed. Biological testing showed that the inhibitor-Tat conjugate was successfully delivered to the lysosomes, leading to potent inhibition of lysosomal cysteine proteases in cultured cells. © 2010 The Royal Society of Chemistry.
Source Title: Chemical Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/75381
ISSN: 13597345
DOI: 10.1039/c0cc03738a
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