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|Title:||"Click" synthesis of small molecule-peptide conjugates for organelle-specific delivery and inhibition of lysosomal cysteine proteases|
|Citation:||Loh, Y., Shi, H., Hu, M., Yao, S.Q. (2010-11-28). "Click" synthesis of small molecule-peptide conjugates for organelle-specific delivery and inhibition of lysosomal cysteine proteases. Chemical Communications 46 (44) : 8407-8409. ScholarBank@NUS Repository. https://doi.org/10.1039/c0cc03738a|
|Abstract:||A click chemistry approach for the synthesis of small molecule inhibitor-peptide conjugates to achieve organelle-specific delivery has been developed. Biological testing showed that the inhibitor-Tat conjugate was successfully delivered to the lysosomes, leading to potent inhibition of lysosomal cysteine proteases in cultured cells. © 2010 The Royal Society of Chemistry.|
|Source Title:||Chemical Communications|
|Appears in Collections:||Staff Publications|
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