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Title: Upconverting fluorescent nanoparticles for biodetection and photoactivation
Authors: Huang, K.
Li, W.
Jayakumar, M.K.G.
Zhang, Y. 
Keywords: Fluorescence
Issue Date: 2013
Citation: Huang, K., Li, W., Jayakumar, M.K.G., Zhang, Y. (2013). Upconverting fluorescent nanoparticles for biodetection and photoactivation. Proceedings of SPIE - The International Society for Optical Engineering 8635 : -. ScholarBank@NUS Repository.
Abstract: Fluorophores including fluorescent dyes/proteins and quantum dots (QDs) are used for fluorescence-based imaging and detection. These are based on 'downconversion fluorescence' and have several drawbacks: photobleaching, autofluorescence, short tissue penetration depth and tissue photo-damage. Upconversion fluorescent nanoparticles (UCNs) emit detectable photons of higher energy in the short wavelength range upon irradiation with near-infrared (NIR) light based on a process termed 'upconversion'. UCNs show absolute photostability, negligible autofluorescence, high penetration depth and minimum photodamage to biological tissues. Lanthanide doped nanocrystals with nearinfrared NIR-to-NIR and/or NIR-to-VIS and/or NIR-to-UV upconversion fluorescence emission have been synthesized. The nanocrystals with small size and tunable multi-color emission have been developed. The emission can be tuned by doping different upconverting lanthanide ions into the nanocrystals. The nanocrystals with core-shell structure have also been prepared to tune the emission color. The surfaces of these nanocrystals have been modified to render them water dispersible and biocompatible. They can be used for ultrasensitive interference-free biodetection because most biomolecules do not have upconversion properties. UCNs are also useful for light based therapy with enhanced efficiency, for example, photoactivation. © 2013 SPIE.
Source Title: Proceedings of SPIE - The International Society for Optical Engineering
ISBN: 9780819494047
ISSN: 0277786X
DOI: 10.1117/12.2002754
Appears in Collections:Staff Publications

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