Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/74912
Title: Pathogen and inflammatory components removal from blood using cell margination
Authors: Hou, H.W.
Gan, H.Y.
Bhagat, A.A.S.
Li, L.D.
Lim, C.T. 
Han, J.
Keywords: Blood separation
Cell sorting
Margination
Red blood cells
Sepsis
Issue Date: 2011
Citation: Hou, H.W.,Gan, H.Y.,Bhagat, A.A.S.,Li, L.D.,Lim, C.T.,Han, J. (2011). Pathogen and inflammatory components removal from blood using cell margination. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 3 : 1912-1914. ScholarBank@NUS Repository.
Abstract: Sepsis is an adverse systemic inflammatory response caused by microbial infection in blood. This paper reports a novel microfluidic approach for non-specific removal of both pathogen and inflammatory cellular components from whole blood directly using cell margination. A high microbial removal efficiency of > 80% was achieved in our device consisting of 2 cascaded microchannels in series, thus allowing a 2-stage removal of microbes in a single step. ∼90% of platelets and leukocytes were also successfully removed from the blood which can be used to modulate the host inflammatory responses and potentially as a blood cleansing method for sepsis treatment.
Source Title: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
URI: http://scholarbank.nus.edu.sg/handle/10635/74912
ISBN: 9781618395955
Appears in Collections:Staff Publications

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