Interactive reference descriptions of cellular electrophysiology models

Abstract

With the advent and popularization of technologies such as CellML and SBML it has become relatively easy to share and exchange mathematical models of biological systems. However, as such technology evolves it is inevitable that not all tools will correctly interpret the full range of models able to be described. It is also necessary to completely describe the mathematical models allowing model users to appropriately use each model. To address these issues we have previously developed methods and tools based on community defined standards which allow for the specification of a reference description of a mathematical model. Such reference descriptions provide a comprehensive description of both the mathematical model and the outcomes expected when performing specific numerical simulations using the model. Thus providing for quantitative validation of tool interpretation of a given model as well as informing the model user as to all aspects of the model definition. Further development of this work has led to the conclusion that presenting such reference descriptions in a user friendly and interactive manner provides a powerful tool for the dissemination and understanding of the mathematical model. Furthermore, such a tool is seen as an invaluable teaching aid in the education of biomedical engineers and scientists allowing for anything from a superficial to a very comprehensive interaction with the mathematical model. © 2008 IEEE.