Please use this identifier to cite or link to this item: https://doi.org/10.1117/12.908652
Title: Detection of malignant lesions in vivo in the upper gastrointestinal tract using image-guided Raman endoscopy
Authors: Bergholt, M.S. 
Zheng, W. 
Lin, K. 
Ho, K.Y.
Yeoh, K.G.
Teh, M.
So, J.B.Y.
Huang, Z. 
Keywords: cancer
esophagus
gastric
in vivo diagnosis
near-infrared Raman spectroscopy
Issue Date: 2012
Citation: Bergholt, M.S., Zheng, W., Lin, K., Ho, K.Y., Yeoh, K.G., Teh, M., So, J.B.Y., Huang, Z. (2012). Detection of malignant lesions in vivo in the upper gastrointestinal tract using image-guided Raman endoscopy. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8219 : -. ScholarBank@NUS Repository. https://doi.org/10.1117/12.908652
Abstract: Raman spectroscopy is a vibrational analytic technique sensitive to the changes in biomolecular composition and conformations occurring in tissue. With our most recent development of near-infrared (NIR) Raman endoscopy integrated with diagnostic algorithms, in vivo real-time Raman diagnostics has been realized under multimodal wide-field imaging (i.e., white- light reflectance (WLR), narrow-band imaging (NBI), autofluorescence imaging (AFI)) modalities. A selection of 177 patients who previously underwent Raman endoscopy (n=2510 spectra) was used to render two robust models based on partial least squares - discriminant analysis (PLS-DA) for esophageal and gastric cancer diagnosis. The Raman endoscopy technique was validated prospectively on 4 new gastric and esophageal patients for in vivo tissue diagnosis. The Raman endoscopic technique could identify esophageal cancer in vivo with a sensitivity of 88.9% (8/9) and specificity of 100.0% (11/11) and gastric cancers with a sensitivity of 77.8% (14/18) and specificity of 100.0% (13/13). This study realizes for the first time the image-guided Raman endoscopy for real-time in vivo diagnosis of malignancies in the esophagus and gastric at the biomolecular level. © 2012 SPIE.
Source Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
URI: http://scholarbank.nus.edu.sg/handle/10635/74847
ISBN: 9780819488626
ISSN: 16057422
DOI: 10.1117/12.908652
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