Please use this identifier to cite or link to this item:
|Title:||A 'microfluidic pinball' for on-chip generation of Layer-by-Layer polyelectrolyte microcapsules|
|Source:||Kantak, C., Beyer, S., Yobas, L., Bansal, T., Trau, D. (2011-03-21). A 'microfluidic pinball' for on-chip generation of Layer-by-Layer polyelectrolyte microcapsules. Lab on a Chip - Miniaturisation for Chemistry and Biology 11 (6) : 1030-1035. ScholarBank@NUS Repository. https://doi.org/10.1039/c0lc00381f|
|Abstract:||Inspired by the game of "pinball" where rolling metal balls are guided by obstacles, here we describe a novel microfluidic technique which utilizes micropillars in a flow channel to continuously generate, encapsulate and guide Layer-by-Layer (LbL) polyelectrolyte microcapsules. Droplet-based microfluidic techniques were exploited to generate oil droplets which were smoothly guided along a row of micropillars to repeatedly travel through three parallel laminar streams consisting of two polymers and a washing solution. Devices were prototyped in PDMS and generated highly monodisperse and stable 45 ± 2 m sized polyelectrolyte microcapsules. A total of six layers of hydrogen bonded polyelectrolytes (3 bi-layers) were adsorbed on each droplet within <3 minutes and a fluorescent intensity measurement confirmed polymer film deposition. AFM analysis revealed the thickness of each polymer layer to be approx. 2.8 nm. Our design approach not only provides a faster and more efficient alternative to conventional LbL deposition techniques, but also achieves the highest number of polyelectrolyte multilayers (PEMs) reported thus far using microfluidics. Additionally, with our design, a larger number of PEMs can be deposited without adding any extra operational or interfacial complexities (e.g. syringe pumps) which are a necessity in most other designs. Based on the aforementioned advantages of our device, it may be developed into a great tool for drug encapsulation, or to create capsules for biosensing where deposition of thin nanofilms with controlled interfacial properties is highly required. © 2011 The Royal Society of Chemistry.|
|Source Title:||Lab on a Chip - Miniaturisation for Chemistry and Biology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 6, 2017
WEB OF SCIENCETM
checked on Nov 19, 2017
checked on Dec 10, 2017
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.