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|Title:||A 'microfluidic pinball' for on-chip generation of Layer-by-Layer polyelectrolyte microcapsules|
|Source:||Kantak, C., Beyer, S., Yobas, L., Bansal, T., Trau, D. (2011-03-21). A 'microfluidic pinball' for on-chip generation of Layer-by-Layer polyelectrolyte microcapsules. Lab on a Chip - Miniaturisation for Chemistry and Biology 11 (6) : 1030-1035. ScholarBank@NUS Repository. https://doi.org/10.1039/c0lc00381f|
|Abstract:||Inspired by the game of "pinball" where rolling metal balls are guided by obstacles, here we describe a novel microfluidic technique which utilizes micropillars in a flow channel to continuously generate, encapsulate and guide Layer-by-Layer (LbL) polyelectrolyte microcapsules. Droplet-based microfluidic techniques were exploited to generate oil droplets which were smoothly guided along a row of micropillars to repeatedly travel through three parallel laminar streams consisting of two polymers and a washing solution. Devices were prototyped in PDMS and generated highly monodisperse and stable 45 ± 2 m sized polyelectrolyte microcapsules. A total of six layers of hydrogen bonded polyelectrolytes (3 bi-layers) were adsorbed on each droplet within <3 minutes and a fluorescent intensity measurement confirmed polymer film deposition. AFM analysis revealed the thickness of each polymer layer to be approx. 2.8 nm. Our design approach not only provides a faster and more efficient alternative to conventional LbL deposition techniques, but also achieves the highest number of polyelectrolyte multilayers (PEMs) reported thus far using microfluidics. Additionally, with our design, a larger number of PEMs can be deposited without adding any extra operational or interfacial complexities (e.g. syringe pumps) which are a necessity in most other designs. Based on the aforementioned advantages of our device, it may be developed into a great tool for drug encapsulation, or to create capsules for biosensing where deposition of thin nanofilms with controlled interfacial properties is highly required. © 2011 The Royal Society of Chemistry.|
|Source Title:||Lab on a Chip - Miniaturisation for Chemistry and Biology|
|Appears in Collections:||Staff Publications|
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