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Title: Investigation of electrostatic behavior of a lactose carrier for dry powder inhalers
Authors: Chow, K.T.
Zhu, K.
Tan, R.B.H. 
Heng, P.W.S. 
Keywords: Aerosol
Dry powder inhaler
Issue Date: Dec-2008
Citation: Chow, K.T., Zhu, K., Tan, R.B.H., Heng, P.W.S. (2008-12). Investigation of electrostatic behavior of a lactose carrier for dry powder inhalers. Pharmaceutical Research 25 (12) : 2822-2834. ScholarBank@NUS Repository.
Abstract: Purpose. This study aims to elucidate the electrostatic behavior of a model lactose carrier used in dry powder inhaler formulations by examining the effects of ambient relative humidity (RH), aerosolization air flow rate, repeated inhaler use, gelatin capsule and tapping on the specific charge (nC/g) of bulk and aerosolized lactose. Materials and Methods. Static and dynamic electrostatic charge measurements were performed using a Faraday cage connected to an electrometer. Experiments were conducted inside a walk-in environmental chamber at 25°C and RHs of 20% to 80%. Aerosolization was achieved using air flow rates of 30, 45, 60 and 75 L/min. Results. The initial charges of the bulk and capsulated lactose were a magnitude lower than the charges of tapped or aerosolized lactose. Dynamic charge increased linearly with aerosolization air flow rate and RH. Greater frictional forces at higher air flow rate induced higher electrostatic charges. Increased RH enhanced charge generation. Repeated inhaler use significantly influenced electrostatic charge due to repeated usage. Conclusions. This study demonstrated the significance of interacting influences by variables commonly encountered in the use DPI such as variation in patient's inspiratory flow rate, ambient RH and repeated inhaler use on the electrostatic behavior of a lactose DPI carrier. © 2008 Springer Science+Business Media, LLC.
Source Title: Pharmaceutical Research
ISSN: 07248741
DOI: 10.1007/s11095-008-9651-y
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