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Title: Control of batch cooling crystallization of glycine
Authors: Chew, J.W.
Black, S.N.
Chow, P.S.
Tan, R.B.H. 
Carpenter, K.J.
Issue Date: 2005
Source: Chew, J.W.,Black, S.N.,Chow, P.S.,Tan, R.B.H.,Carpenter, K.J. (2005). Control of batch cooling crystallization of glycine. AIChE Annual Meeting, Conference Proceedings : 9010-9016. ScholarBank@NUS Repository.
Abstract: Traditionally, temperature control strategies are used for cooling crystallization, whereby the temperature of the solution is controlled to follow a pre-set cooling profile determined in the laboratory from small scale crystallization experiments. In recent years, with the advancement in in-line technologies for measuring particles and solution concentrations, more sophisticated control strategies have been proposed by various researchers. The benefits claimed for such new approaches are more consistent product and easier scale-up. Therefore, the main purpose of this paper is to evaluate the benefits, or lack thereof, of new methods for controlling crystallizations over conventional methods using temperature-control. The present work uses glycine-water as a model system to demonstrate the effects of the various modes of crystallization process control and of scale-up. In-line sensors, including FTIR-ATR and Lasentec FBRM, have been used to monitor the cooling crystallization of glycine. Making use of information from the sensors, different control strategies have been implemented. Industrial applicability, especially with regards to practicality and robustness will be discussed.
Source Title: AIChE Annual Meeting, Conference Proceedings
Appears in Collections:Staff Publications

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