Please use this identifier to cite or link to this item: https://doi.org/10.1109/CCA.2006.286194
Title: A run-to-run control strategy for polymorphic transformation in pharmaceutical crystallization
Authors: Hermanto, M.W.
Braatz, R.D.
Chiu, M.-S. 
Issue Date: 2007
Source: Hermanto, M.W.,Braatz, R.D.,Chiu, M.-S. (2007). A run-to-run control strategy for polymorphic transformation in pharmaceutical crystallization. Proceedings of the IEEE International Conference on Control Applications : 2121-2126. ScholarBank@NUS Repository. https://doi.org/10.1109/CCA.2006.286194
Abstract: Polymorphism is a phenomenon that a substance can have more than one crystal form, each with distinct characteristics. Consequently, controlling polymorphism in drug manufacturing industries are crucial in order to ensure consistent production of the desired polymorph. In this paper, a run-to-run concentration control (C-control) based on iterative learning control is developed. As a case study, a model of polymorphic transformation of L-Glutamic acid from metastable a-form to stable β-form, where the yield of β-form is to be maximized, is used to illustrate the proposed run-to-run C-control and its advantage over the conventional C-control. ©2006 IEEE.
Source Title: Proceedings of the IEEE International Conference on Control Applications
URI: http://scholarbank.nus.edu.sg/handle/10635/74460
ISBN: 0780397959
DOI: 10.1109/CCA.2006.286194
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

29
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.