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|Title:||Automaton models of computational genetic regulatory networks with combinatorial gene-protein logical interactions|
|Authors:||Chen, P.C.Y. |
|Source:||Chen, P.C.Y., Weng, Y. (2009). Automaton models of computational genetic regulatory networks with combinatorial gene-protein logical interactions. Proceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009 : 301-307. ScholarBank@NUS Repository. https://doi.org/10.1109/IJCBS.2009.94|
|Abstract:||This article presents a formal framework for modeling computational genetic regulatory networks as automata, with multi-threshold protein concentration and combinatorial logical gene-protein interactions. By computing the intersection of the languages generated by these automata we obtain the complete set of pathways in a gene network. We illustrate the effectiveness of our framework in the modeling of (i) morphogenesis in Arabidopsis and (ii) regulation in phage λ. © 2009 IEEE.|
|Source Title:||Proceedings - 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing, IJCBS 2009|
|Appears in Collections:||Staff Publications|
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