Please use this identifier to cite or link to this item: https://doi.org/10.1205/cherd06234
Title: Recent advances in crystallization control: An industrial perspective
Authors: Yu, Z.Q.
Chew, J.W.
Chow, P.S.
Tan, R.B.H. 
Keywords: Crystal habit
Crystallization
PAT
Polymorph control
PSD
Quality by design
Issue Date: Jul-2007
Source: Yu, Z.Q., Chew, J.W., Chow, P.S., Tan, R.B.H. (2007-07). Recent advances in crystallization control: An industrial perspective. Chemical Engineering Research and Design 85 (7 A) : 893-905. ScholarBank@NUS Repository. https://doi.org/10.1205/cherd06234
Abstract: Crystallization is the most important unit operation for the separation and purification of chemicals in the pharmaceutical and fine chemical industries. Crystallization processes in pharmaceutical active ingredient manufacturing have been traditionally a recipe-based operations, offering little scope for dynamic process control and improvement. With the change in regulatory climate from quality-by-testing (QbT) to quality-by-design (QbD) and with the advent of the process analytical technology (PAT) initiative, it is timely to examine the impact of such quality-based emphasis on crystallization control. In this paper, we review the important recent developments in the control of crystallization process, and discuss their feasibility and scope for implementation in industrial processes. The control methods to achieve different aspects of crystal product quality, including particle size distribution (PSD), crystal habit and polymorphic form, are discussed separately. © 2007 Institution of Chemical Engineers.
Source Title: Chemical Engineering Research and Design
URI: http://scholarbank.nus.edu.sg/handle/10635/68386
ISSN: 02638762
DOI: 10.1205/cherd06234
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