Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00253-010-3037-x
Title: Polyrotaxanes for applications in life science and biotechnology
Authors: Li, J.J.
Zhao, F.
Li, J. 
Keywords: Cyclodextrin
Drug delivery
Gene delivery
Polypseudorotaxane
Polyrotaxane
Tissue engineering
Issue Date: Apr-2011
Source: Li, J.J., Zhao, F., Li, J. (2011-04). Polyrotaxanes for applications in life science and biotechnology. Applied Microbiology and Biotechnology 90 (2) : 427-443. ScholarBank@NUS Repository. https://doi.org/10.1007/s00253-010-3037-x
Abstract: Due to their low cytotoxicity, controllable size, and unique architecture, cyclodextrin (CD)-based polyrotaxanes and polypseudorotaxanes have inspired interesting exploitation as novel biomaterials. This review will update the recent progress in the studies on the structures of polyrotaxanes and polypseudorotaxanes based on different CDs and polymers, followed by summarizing their potential applications in life science and biotechnology, such as drug delivery, gene delivery, and tissue engineering. CD-based biodegradable polypseudorotaxane hydrogels could be used as promising injectable drug delivery systems for sustained and controlled drug release. Polyrotaxanes with drug or ligand-conjugated CDs threaded on polymer chain with biodegradable end group could be useful for controlled and multivalent targeting delivery. Cationic polyrotaxanes consisting of multiple oligoethylenimine-grafted CDs threaded on a block copolymer chain were attractive non-viral gene carries due to the strong DNA-binding ability, low cytotoxicity, and high gene transfection efficiency. Cytocleavable end caps were also introduced in the polyrotaxane systems in order to ensure efficient endosomal escape for intracellular trafficking of DNA. Finally, hydrolyzable polyrotaxane hydrogels with cross-linked α-CDs could be a desirable scaffold for cartilage and bone tissue engineering. © 2011 Springer-Verlag.
Source Title: Applied Microbiology and Biotechnology
URI: http://scholarbank.nus.edu.sg/handle/10635/68375
ISSN: 01757598
DOI: 10.1007/s00253-010-3037-x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

66
checked on Dec 5, 2017

WEB OF SCIENCETM
Citations

58
checked on Dec 5, 2017

Page view(s)

20
checked on Dec 11, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.