Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biotechadv.2011.07.001
Title: Immunoglobulin-M purification - challenges and perspectives
Authors: Gautam, S.
Loh, K.-C. 
Keywords: Affinity chromatography
Biomimetic ligands
Immunoglobulin-M
Purification
Issue Date: Nov-2011
Source: Gautam, S.,Loh, K.-C. (2011-11). Immunoglobulin-M purification - challenges and perspectives. Biotechnology Advances 29 (6) : 840-849. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biotechadv.2011.07.001
Abstract: Extensive research in the past two decades has led to the realization of Immunoglobulin-M (IgM) as a potential therapeutic and diagnostic agent. In order to fully exploit the potential of IgM, large quantities, in a highly pure and active form, must be available at low cost for performing clinical trials, characterization studies and quantitative-structure activity analyses. The complex physico-chemical properties, in particular its large size and labile nature renders downstream purification of IgM difficult. This review discusses the limitations and challenges associated with the current IgM purification strategies and proposes future directions for research. The uniqueness of affinity chromatography, specifically biomimetic affinity chromatography for protein purification is highlighted and its potential for IgM purification is discussed. © 2011 Elsevier Inc.
Source Title: Biotechnology Advances
URI: http://scholarbank.nus.edu.sg/handle/10635/68272
ISSN: 07349750
DOI: 10.1016/j.biotechadv.2011.07.001
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