Please use this identifier to cite or link to this item: https://doi.org/10.4161/org.25425
Title: High throughput screening to investigate the interaction of stem cells with their extracellular microenvironment
Authors: Ankam, S.
Teo, B.K.K.
Kukumberg, M.
Yim, E.K.F. 
Keywords: Biomaterials
Biotechnology
Differentiation
Extracellular matrix
Maintenance
Microarray
Niche
Proliferation
Stiffness
Topography
Issue Date: Jul-2013
Source: Ankam, S., Teo, B.K.K., Kukumberg, M., Yim, E.K.F. (2013-07). High throughput screening to investigate the interaction of stem cells with their extracellular microenvironment. Organogenesis 9 (3) : 194-208. ScholarBank@NUS Repository. https://doi.org/10.4161/org.25425
Abstract: Stem cells in vivo are housed within a functional microenvironment termed the "stem cell niche." As the niche components can modulate stem cell behaviors like proliferation, migration and differentiation, evaluating these components would be important to determine the most optimal platform for their maintenance or differentiation. In this review, we have discussed methods and technologies that have aided in the development of high throughput screening assays for stem cell research, including enabling technologies such as the established multiwell/microwell plates and robotic spotting, and emerging technologies like microfluidics, micro-contact printing and lithography. We also discuss the studies that utilized high throughput screening platform to investigate stem cell response to extracellular matrix, topography, biomaterials and stiffness gradients in the stem cell niche. The combination of the aforementioned techniques could lay the foundation for new perspectives in further development of high throughput technology and stem cell research. © 2013 Landes Bioscience.
Source Title: Organogenesis
URI: http://scholarbank.nus.edu.sg/handle/10635/68268
ISSN: 15476278
DOI: 10.4161/org.25425
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