Please use this identifier to cite or link to this item: https://doi.org/10.1098/rsif.2011.0301
Title: Biomaterial strategies for alleviation of myocardial infarction
Authors: Venugopal, J.R. 
Prabhakaran, M.P. 
Mukherjee, S.
Ravichandran, R.
Dan, K.
Ramakrishna, S. 
Keywords: Biomaterials
Cardiomyocytes
Hydrogels
Injectables
Mesenchymal stem cells
Myocardial infarction
Issue Date: 7-Jan-2012
Source: Venugopal, J.R., Prabhakaran, M.P., Mukherjee, S., Ravichandran, R., Dan, K., Ramakrishna, S. (2012-01-07). Biomaterial strategies for alleviation of myocardial infarction. Journal of the Royal Society Interface 9 (66) : 1-19. ScholarBank@NUS Repository. https://doi.org/10.1098/rsif.2011.0301
Abstract: World Health Organization estimated that heart failure initiated by coronary artery disease and myocardial infarction (MI) leads to 29 per cent of deaths worldwide. Heart failure is one of the leading causes of death in industrialized countries and is expected to become a global epidemic within the twenty-first century. MI, the main cause of heart failure, leads to a loss of cardiac tissue impairment of left ventricular function. The damaged left ventricle undergoes progressive 'remodelling' and chamber dilation, with myocyte slippage and fibroblast proliferation. Repair of diseased myocardium with in vitro-engineered cardiac muscle patch/injectable biopolymers with cells may become a viable option for heart failure patients. These events reflect an apparent lack of effective intrinsic mechanism for myocardial repair and regeneration. Motivated by the desire to develop minimally invasive procedures, the last 10 years observed growing efforts to develop injectable biomaterials with and without cells to treat cardiac failure. Biomaterials evaluated include alginate, fibrin, collagen, chitosan, self-assembling peptides, biopolymers and a range of synthetic hydrogels. The ultimate goal in therapeutic cardiac tissue engineering is to generate biocompatible, non-immunogenic heart muscle with morphological and functional properties similar to natural myocardium to repair MI. This review summarizes the properties of biomaterial substrates having sufficient mechanical stability, which stimulates the native collagen fibril structure for differentiating pluripotent stem cells and mesenchymal stem cells into cardiomyocytes for cardiac tissue engineering. This journal is © 2011 The Royal Society.
Source Title: Journal of the Royal Society Interface
URI: http://scholarbank.nus.edu.sg/handle/10635/68144
ISSN: 17425689
DOI: 10.1098/rsif.2011.0301
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

106
checked on Dec 13, 2017

WEB OF SCIENCETM
Citations

89
checked on Nov 15, 2017

Page view(s)

31
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.