Please use this identifier to cite or link to this item: https://doi.org/10.1002/pi.2108
Title: Biodegradable polymers applied in tissue engineering research: A review
Authors: Martina, M.
Hutmacher, D.W. 
Keywords: Biodegradable polymers
Matrices
Scaffolds
Tissue engineering
Issue Date: Feb-2007
Source: Martina, M., Hutmacher, D.W. (2007-02). Biodegradable polymers applied in tissue engineering research: A review. Polymer International 56 (2) : 145-157. ScholarBank@NUS Repository. https://doi.org/10.1002/pi.2108
Abstract: Typical applications and research areas of polymeric biomaterials include tissue replacement, tissue augmentation, tissue support, and drug delivery. In many cases the body needs only the temporary presence of a device/biomaterial, in which instance biodegradable and certain partially biodegradable polymeric materials are better alternatives than biostable ones. Recent treatment concepts based on scaffold-based tissue engineering principles differ from standard tissue replacement and drug therapies as the engineered tissue aims not only to repair but also regenerate the target tissue. Cells have been cultured outside the body for many years; however, it has only recently become possible for scientists and engineers to grow complex three-dimensional tissue grafts to meet clinical needs. New generations of scaffolds based on synthetic and natural polymers are being developed and evaluated at a rapid pace, aimed at mimicking the structural characteristics of natural extracellular matrix. This review focuses on scaffolds made of more recently developed synthetic polymers for tissue engineering applications. Currently, the design and fabrication of biodegradable synthetic scaffolds is driven by four material categories: (i) common clinically established polymers, including polyglycolide, polylactides, polycaprolactone; (ii) novel di- and tri-block polymers; (iii) newly synthesized or studied polymeric biomaterials, such as polyorthoester, polyanhydrides, polyhydroxyalkanoate, polypyrroles, poly(ether ester amide)s, elastic shape-memory polymers; and (iv) biomimetic materials, supramolecular polymers formed by self-assembly, and matrices presenting distinctive or a variety of biochemical cues. This paper aims to review the latest developments from a scaffold material perspective, mainly pertaining to categories (ii) and (iii) listed above. © 2006 Society of Chemical Industry.
Source Title: Polymer International
URI: http://scholarbank.nus.edu.sg/handle/10635/68141
ISSN: 09598103
DOI: 10.1002/pi.2108
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

247
checked on Dec 13, 2017

WEB OF SCIENCETM
Citations

222
checked on Nov 16, 2017

Page view(s)

59
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.