Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2013.04.046
Title: Variation of the effect of calcium phosphate enhancement of implanted silk fibroin ligament bone integration
Authors: Shi, P. 
Teh, T.K.H. 
Toh, S.L. 
Goh, J.C.H. 
Keywords: Bone and regeneration
Hydroxyapatite
Ligament
Silk
Issue Date: Aug-2013
Source: Shi, P., Teh, T.K.H., Toh, S.L., Goh, J.C.H. (2013-08). Variation of the effect of calcium phosphate enhancement of implanted silk fibroin ligament bone integration. Biomaterials 34 (24) : 5947-5957. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2013.04.046
Abstract: In this article, low crystallinity hydroxyapatite (LHA) is developed and utilized to modify silk fibroin scaffolds which are applied to repair bone/ligament defects successfully. It can promote osteogenesis which is authenticated through invitro and invivo tests. The scaffold is an efficient carrier, supporting cell proliferation and differentiation. Meanwhile, cytocompatibility and osteoblastic gene expressions (RUNX2 and osteocalcin, for example) of rabbit's bone marrow derived mesenchymal stem cells (MSCs) are significantly boosted on LHA/silk scaffold. Further, for animal trial, almost 60% of bone volume and 80% of original mechanical strength are recovered after 4 months' bone/ligament regeneration in bone tunnel of rabbit model, where significant amount of bone tissue regeneration is also confirmed by data of histological evaluation and micro computed tomography (μ-CT). Hence, the invented scaffold is applicable for ligament/bone regeneration in future lager animal and clinical trials. © 2013 Elsevier Ltd.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/67345
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2013.04.046
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