Please use this identifier to cite or link to this item: https://doi.org/10.1038/nmat3363
Title: Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides
Authors: Zhang, Y.
Zheng, F.
Yang, T.
Zhou, W.
Liu, Y.
Man, N.
Zhang, L.
Jin, N.
Dou, Q.
Zhang, Y. 
Li, Z.
Wen, L.-P.
Issue Date: Sep-2012
Source: Zhang, Y., Zheng, F., Yang, T., Zhou, W., Liu, Y., Man, N., Zhang, L., Jin, N., Dou, Q., Zhang, Y., Li, Z., Wen, L.-P. (2012-09). Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides. Nature Materials 11 (9) : 817-826. ScholarBank@NUS Repository. https://doi.org/10.1038/nmat3363
Abstract: The induction of autophagy on exposure of cells to a variety of nanoparticles represents both a safety concern and an application niche for engineered nanomaterials. Here, we show that a short synthetic peptide, RE-1, identified by means of phage display, binds to lanthanide (LN) oxide and upconversion nanocrystals (UCN), forms a stable coating layer on the nanoparticlesĝ™ surface, and effectively abrogates their autophagy-inducing activity. Furthermore, RE-1 peptide variants exhibit a differentially reduced binding capability, and correspondingly, a varied ability to reduce the autophagic response. We also show that the addition of an arginineg-glycineg-aspartic acid (RGD) motif to RE-1 enhances autophagy for LN UCN through the interaction with integrins. RE-1 and its variants provide a versatile tool for tuning materialg-cell interactions to achieve the desired level of autophagy, and may prove useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices. © 2012 Macmillan Publishers Limited. All rights reserved.
Source Title: Nature Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/67337
ISSN: 14761122
DOI: 10.1038/nmat3363
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

86
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

86
checked on Nov 21, 2017

Page view(s)

44
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.