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Title: Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides
Authors: Zhang, Y.
Zheng, F.
Yang, T.
Zhou, W.
Liu, Y.
Man, N.
Zhang, L.
Jin, N.
Dou, Q.
Zhang, Y. 
Li, Z.
Wen, L.-P.
Issue Date: Sep-2012
Citation: Zhang, Y., Zheng, F., Yang, T., Zhou, W., Liu, Y., Man, N., Zhang, L., Jin, N., Dou, Q., Zhang, Y., Li, Z., Wen, L.-P. (2012-09). Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides. Nature Materials 11 (9) : 817-826. ScholarBank@NUS Repository.
Abstract: The induction of autophagy on exposure of cells to a variety of nanoparticles represents both a safety concern and an application niche for engineered nanomaterials. Here, we show that a short synthetic peptide, RE-1, identified by means of phage display, binds to lanthanide (LN) oxide and upconversion nanocrystals (UCN), forms a stable coating layer on the nanoparticlesĝ™ surface, and effectively abrogates their autophagy-inducing activity. Furthermore, RE-1 peptide variants exhibit a differentially reduced binding capability, and correspondingly, a varied ability to reduce the autophagic response. We also show that the addition of an arginineg-glycineg-aspartic acid (RGD) motif to RE-1 enhances autophagy for LN UCN through the interaction with integrins. RE-1 and its variants provide a versatile tool for tuning materialg-cell interactions to achieve the desired level of autophagy, and may prove useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices. © 2012 Macmillan Publishers Limited. All rights reserved.
Source Title: Nature Materials
ISSN: 14761122
DOI: 10.1038/nmat3363
Appears in Collections:Staff Publications

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