Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jcis.2004.09.042
Title: Surface modification of monodisperse magnetite nanoparticles for improved intracellular uptake to breast cancer cells
Authors: Zhang, Y. 
Zhang, J.
Keywords: Folic acid
Intracellular uptake
Magnetite nanoparticles
PEG
PEG-FA
Issue Date: 15-Mar-2005
Source: Zhang, Y., Zhang, J. (2005-03-15). Surface modification of monodisperse magnetite nanoparticles for improved intracellular uptake to breast cancer cells. Journal of Colloid and Interface Science 283 (2) : 352-357. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jcis.2004.09.042
Abstract: Nanoparticles have been widely used for a variety of biomedical applications and there is a growing need for highly specific and efficient uptake of the nanoparticles into target cells. Poly(ethylene glycol) (PEG), folic acid (FA), and their conjugate PEG-FA were attached to magnetite nanoparticles to compare their effects on the improvement of intracellular uptake of the nanoparticles to human breast cancer cells, BT-20. AFM and TEM results indicated that the nanoparticles after surface modification were monodisperse, with coatings on individual nanoparticles. The cell culture experiments showed that the PEG-FA coated nanoparticles were internalized into BT-20 cancer cells and exhibited higher efficiency of intracellular uptake than only PEG- or FA-coated nanoparticles. The surface modification protocols can also be used to modify the surfaces of other nanoparticles for targeting intracellular delivery. © 2004 Elsevier Inc. All rights reserved.
Source Title: Journal of Colloid and Interface Science
URI: http://scholarbank.nus.edu.sg/handle/10635/67296
ISSN: 00219797
DOI: 10.1016/j.jcis.2004.09.042
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