Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.a.30410
Title: Surface modification of gold and quantum dot nanoparticles with chitosan for bioapplications
Authors: Tan, W.B. 
Zhang, Y. 
Keywords: Biocompatibility
Chitosan
Gold
Nanoparticle
Quantum dot
Issue Date: 1-Oct-2005
Source: Tan, W.B., Zhang, Y. (2005-10-01). Surface modification of gold and quantum dot nanoparticles with chitosan for bioapplications. Journal of Biomedical Materials Research - Part A 75 (1) : 56-62. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.30410
Abstract: Gold (Au) and quantum dot (QD) nanoparticles, which have been extensively used in many fields, were encapsulated with a natural polymer, chitosan, to improve their biocompatibility. Characterization was performed using ultraviolet-visible, dynamic light scattering, atomic force microscopy, and transmission electron microscope analyses. It was found that a Au/chitosan ratio of 1:1 and smaller produced chitosan-encapsulated Au nanoparticles of a sufficiently small size, and this result was then applied in the chitosan encapsulation of QDs. The biocompatibility of both types of nanoparticles was assessed in cell culture studies using HT29 human colon carcinoma and NIH 3T3 mouse fibroblast cells, MTT and trypan blue exclusion assays revealed that both chitosan-encapsulated Au nanoparticles and QDs exhibited improved biocompatibility over their bare, nonencapsulated counterparts. Therefore, this study showed that chitosan could be used to encapsulate both Au nanoparticles and QDs in order to enhance their biocompatibility. The approaches developed in this study can also be extended to other nanoparticles for bioapplications as well. © 2005 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part A
URI: http://scholarbank.nus.edu.sg/handle/10635/67295
ISSN: 00219304
DOI: 10.1002/jbm.a.30410
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