Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2006.03.025
Title: Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and α-cyclodextrin for controlled drug delivery
Authors: Li, J. 
Li, X.
Ni, X.
Wang, X.
Li, H.
Leong, K.W.
Keywords: Cyclodextrin
Drug delivery
Injectable hydrogel
Self-assembly
Supramolecule
Triblock copolymer
Issue Date: Aug-2006
Source: Li, J., Li, X., Ni, X., Wang, X., Li, H., Leong, K.W. (2006-08). Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and α-cyclodextrin for controlled drug delivery. Biomaterials 27 (22) : 4132-4140. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2006.03.025
Abstract: A materials design of a new supramolecular hydrogel self-assembled between α-cyclodextrin and a biodegradable poly(ethylene oxide)-poly[(r)-3-hydroxybutyrate]-poly(ethylene oxide) (PEO-PHB-PEO) triblock copolymer was demonstrated. The cooperation effect of complexation of PEO segments with α-cyclodextrin and the hydrophobic interaction between PHB blocks resulted in the formation of the supramolecular hydrogel with a strong macromolecular network. The in vitro release kinetics studies of fluorescein isothiocyanate labeled dextran (dextran-FITC) model drug from the hydrogel showed that the hydrogel was suitable for relatively long-term sustained controlled release of macromolecular drugs, which many simple triblock copolymer hydrogel systems could not achieve. The hydrogel was found to be thixotropic and reversible, and can be applied as a promising injectable drug delivery system. © 2006 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/67269
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2006.03.025
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