Please use this identifier to cite or link to this item:
|Title:||Proliferation and differentiation of human osteoblasts within 3D printed poly-lactic-co-glycolic acid scaffolds|
|Authors:||Ge, Z. |
|Source:||Ge, Z., Wang, L., Heng, B.C., Tian, X.-F., Lu, K., Fan, V.T.W., Yeo, J.F., Cao, T., Tan, E. (2009). Proliferation and differentiation of human osteoblasts within 3D printed poly-lactic-co-glycolic acid scaffolds. Journal of Biomaterials Applications 23 (6) : 533-547. ScholarBank@NUS Repository. https://doi.org/10.1177/0885328208094301|
|Abstract:||Bone repair and regeneration can be enhanced through implantation of biocompatible and biodegradable scaffolds, which serve primarily as osteoconductive moieties. In this study, the mechanical properties and microenviroment of 3D printed poly-lactic-co-glycolic acid (PLGA) scaffolds are examined. Additionally, the proliferation and differentiation of human fetal osteoblasts are evaluated after 3 weeks of in vitro culture on the scaffolds. The results showed that the PLGA scaffolds examined had mechanical properties similar to that of trabecular bone, but was still much weaker compared to cortical bone. In addition to general porosity, the PLGA scaffolds also had micropores within macropore walls. Cultured human osteoblasts could proliferate upon seeding on the PLGA scaffolds. Alkaline phosphatase activity and osteonectin expression of the osteoblasts cultured on the PLGA scaffolds remained stable over three weeks, whilst expression of collagen type I and osteopontin decreased. The alkaline phosphatase activity of osteoblasts cultured on PLGA scaffolds is comparable with that from two commercially-available scaffolds - OPLA and collagen scaffolds (Becton-Dickinson (BD) Inc., Franklin Lakes, NJ, USA). Hence, the results suggested that the PLGA scaffolds examined are conducive for promoting osteogenesis. © SAGE Publications, Inc. 2009.|
|Source Title:||Journal of Biomaterials Applications|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 5, 2018
WEB OF SCIENCETM
checked on Mar 5, 2018
checked on Feb 25, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.