Please use this identifier to cite or link to this item: https://doi.org/10.1007/s12195-011-0163-1
Title: Probing the chemo-mechanical effects of an anti-cancer drug emodin on breast cancer cells
Authors: Wuang, S.C. 
Ladoux, B.
Lim, C.T. 
Keywords: Cell traction forces
Cell-matrix interactions
Cellmechanics
Chemo-mechanobiology
Human diseases
Micropillar assay
Issue Date: Sep-2011
Citation: Wuang, S.C., Ladoux, B., Lim, C.T. (2011-09). Probing the chemo-mechanical effects of an anti-cancer drug emodin on breast cancer cells. Cellular and Molecular Bioengineering 4 (3) : 466-475. ScholarBank@NUS Repository. https://doi.org/10.1007/s12195-011-0163-1
Abstract: The anti-cancer drug, emodin, can cause significant mechanobiological changes in human cancer cells, due to the interplay of anti-cell adhesion, actin-disrupting and apoptosis-causing effects of the drug. Here, we used micropillars to monitor the changes in traction forces induced by breast cancer cells in response to this drug stimulus. Our results showed that the variations in the cell traction forces reflected changes in the cytoskeleton integrity and cell behavior. Cell traction forces were found to increase during cell rounding and decrease during the onset of apoptosis and cytoskeleton disruption. These results can provide useful insights into the chemo-mechanical relationships arising from the cell-matrix interactions and can potentially help in the quantitative assessment of drug efficacy. © 2011 Biomedical Engineering Society.
Source Title: Cellular and Molecular Bioengineering
URI: http://scholarbank.nus.edu.sg/handle/10635/67238
ISSN: 18655025
DOI: 10.1007/s12195-011-0163-1
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