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Title: Photodynamic inactivation of viruses using upconversion nanoparticles
Authors: Lim, M.E.
Lee, Y.-L. 
Zhang, Y. 
Chu, J.J.H.
Keywords: Nanoparticle
Photodynamic therapy
Viral pathogen
Issue Date: Feb-2012
Citation: Lim, M.E., Lee, Y.-L., Zhang, Y., Chu, J.J.H. (2012-02). Photodynamic inactivation of viruses using upconversion nanoparticles. Biomaterials 33 (6) : 1912-1920. ScholarBank@NUS Repository.
Abstract: Photodynamic therapy (PDT) is a promising treatment modality that utilizes light of an appropriate wavelength to excite photosensitive materials called photosensitizers, which upon excitation, generate reactive oxygen species (ROS) that are cytocidal and virucidal. However, problems such as hydrophobicity of photosensitizers and limited tissue penetration ability of the current light sources impeded its promotion as a mainstay in medical technology. Here, by using near-infrared (NIR)-to-visible upconversion nanoparticles (UCNs), we demonstrate UCN-based photodynamic inactivation as a potential antiviral strategy. These UCNs are nanotransducers which not only act as carriers of photosensitizers but also active participants in PDT by transducing NIR radiation to visible emissions appropriate for excitation of the attached photosensitizers. The UCNs effectively reduced the infectious virus titers in vitro with no clear pathogenicity in murine model and increased target specificity to virus-infected cells. Hence, this is a promising antiviral approach with feasible applications in the treatments of virus-associated infections, lesions and cancers. © 2011 Elsevier Ltd.
Source Title: Biomaterials
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2011.11.033
Appears in Collections:Staff Publications

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