Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00702-011-0672-z
Title: Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder
Authors: Kurnianingsih, Y.A.
Kuswanto, C.N.
McIntyre, R.S.
Qiu, A. 
Ho, B.C.
Sim, K.
Keywords: Bipolar disorder
Genetic
Neurocognitive
Neuroimaging
Schizophrenia
Issue Date: Nov-2011
Source: Kurnianingsih, Y.A., Kuswanto, C.N., McIntyre, R.S., Qiu, A., Ho, B.C., Sim, K. (2011-11). Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder. Journal of Neural Transmission 118 (11) : 1621-1639. ScholarBank@NUS Repository. https://doi.org/10.1007/s00702-011-0672-z
Abstract: Studies examining intermediate phenotypes such as neurocognitive and neuroanatomical measures along with susceptibility genes are important for improving our understanding of the neural basis of schizophrenia (SZ) and bipolar disorder (BD). In this paper, we review extant studies involving neurocognitive-genetic and neuroimaging genetic perspectives and particularly related to catechol O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin-1 (NRG1) genes in SZ and BD. In terms of neurocognitive-genetic investigations, COMT and BDNF are the two most studied candidate genes especially in patients with SZ. Whereas BDNF Met carriers perform worse on verbal working memory, problem solving and visuo-spatial abilities, COMT Met carriers perform better in working memory, attention, executive functioning with evidence of genotype by diagnosis interactions including high-risk individuals. In terms of genetic-structural MRI studies, patients with SZ are found to have reductions in the frontal, temporal, parietal cortices, and limbic regions, which are associated with BDNF, COMT, and NRGI genes. Genetic-functional MRI studies in psychotic disorders are sparse, especially with regard to BD. These neurocognitive and neuroimaging findings are associated with genes which are implicated in functional pathways related to neuronal signaling, inter-neuronal communication and neuroplasticity. © 2011 Springer-Verlag.
Source Title: Journal of Neural Transmission
URI: http://scholarbank.nus.edu.sg/handle/10635/67193
ISSN: 03009564
DOI: 10.1007/s00702-011-0672-z
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

18
checked on Dec 7, 2017

WEB OF SCIENCETM
Citations

14
checked on Nov 22, 2017

Page view(s)

38
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.