Please use this identifier to cite or link to this item:
Title: Multiscale modelling of human gastric electric activity: Can the electrogastrogram detect functional electrical uncoupling?
Authors: Buist, M.L. 
Cheng, L.K.
Sanders, K.M.
Pullan, A.J.
Issue Date: Mar-2006
Citation: Buist, M.L., Cheng, L.K., Sanders, K.M., Pullan, A.J. (2006-03). Multiscale modelling of human gastric electric activity: Can the electrogastrogram detect functional electrical uncoupling?. Experimental Physiology 91 (2) : 383-390. ScholarBank@NUS Repository.
Abstract: During recent years there has been a growing interest in the assessment of gastric electrical health through cutaneous abdominal recordings. The analysis of such recordings is largely limited to an inspection of frequency dynamics, and this has raised doubts as to whether functional gastric electrical uncoupling can be detected using this technique. We describe here a computational approach to the problem in which the equations governing the underlying physics of the problem have been solved over an anatomically detailed human torso geometry. Cellular electrical activity was embedded within a stomach tissue model, and this was coupled to the torso using an equivalent current source approach. Simulations were performed in which normal and functionally uncoupled (through the introduction of an ectopic antral pacemaker) gastric slow wave activity was present, and corresponding cutaneous electrogastrograms were produced. These were subsequently analysed using the currently recommended techniques, and it was found that the functionally uncoupled situation was indistinguishable from normal slow wave activity using this approach. © 2006 The Authors.
Source Title: Experimental Physiology
ISSN: 09580670
DOI: 10.1113/expphysiol.2005.031021
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Oct 18, 2018


checked on Oct 10, 2018

Page view(s)

checked on Jun 29, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.