Please use this identifier to cite or link to this item: https://doi.org/10.1364/OE.20.012166
Title: Multi-contrast focal modulation microscopy for in vivo imaging of thick biological tissues
Authors: Chen, N. 
Gao, G. 
Issue Date: 21-May-2012
Source: Chen, N., Gao, G. (2012-05-21). Multi-contrast focal modulation microscopy for in vivo imaging of thick biological tissues. Optics Express 20 (11) : 12166-12170. ScholarBank@NUS Repository. https://doi.org/10.1364/OE.20.012166
Abstract: In vivo high resolution imaging of biological tissues is desirable for a wide range of biomedical applications. Recently focal modulation microscopy (FMM) has been developed and an imaging depth comparable to multi-photon microscopy (MPM) and optical coherence microscopy (OCM) has been achieved. Here we report the first focal modulation microscope that is capable of performing real-time fluorescence and scattering imaging simultaneously on thick biological tissues. A novel spatiotemporal phase modulator (STPM) has been designed and integrated into such a microscope to achieve high performances in terms of imaging speed, contrast, effective spatial resolution, signal to noise ratio, and compatibility with multiple excitation wavelengths. © 2012 Optical Society of America.
Source Title: Optics Express
URI: http://scholarbank.nus.edu.sg/handle/10635/67172
ISSN: 10944087
DOI: 10.1364/OE.20.012166
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