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Title: Modulation of NO bioavailability by temporal variation of the cell-free layer width in small arterioles
Authors: Ong, P.K.
Jain, S.
Kim, S. 
Keywords: Microcirculation
Nitric oxide
Wall shear stress
Issue Date: Mar-2011
Citation: Ong, P.K., Jain, S., Kim, S. (2011-03). Modulation of NO bioavailability by temporal variation of the cell-free layer width in small arterioles. Annals of Biomedical Engineering 39 (3) : 1012-1023. ScholarBank@NUS Repository.
Abstract: The cell-free layer exhibits dynamic characteristics in the time domain that may be capable of altering nitric oxide (NO) bioavailability in small arterioles. However, this effect has not been fully elucidated. This study utilized a computational model on NO transport to predict how temporal variations in the layer width could modulate NO bioavailability in the arterioles. Data on the layer width was acquired from high-speed video recordings in arterioles (ID = 48.4 ± 1.8 μm) of the rat cremaster muscle. We found that when wall shear stress response was not considered, the layer variability could lead to a slight decrease (1.6-6.6%) in NO bioavailability that was independent of transient changes in NO scavenging rate. Conversely, the transient response in wall shear stress and NO production rate played a dominant role in reversing this decline such that a significant augmentation (5.3-21.0%) in NO bioavailability was found with increasing layer variability from 24.6 to 63.8%. This study highlighted the importance of the temporal changes in wall shear stress and NO production rate caused by the layer width variations in prediction of NO bioavailability in arterioles. © 2010 Biomedical Engineering Society.
Source Title: Annals of Biomedical Engineering
ISSN: 00906964
DOI: 10.1007/s10439-010-0216-y
Appears in Collections:Staff Publications

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