Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jtbi.2006.03.004
Title: Modelling slow wave activity in the small intestine
Authors: Lin, A.S.-H.
Buist, M.L. 
Smith, N.P.
Pullan, A.J.
Keywords: Biophysical modelling
Interstitial cells of Cajal
Slow wave
Small intestine modelling
Issue Date: 21-Sep-2006
Source: Lin, A.S.-H., Buist, M.L., Smith, N.P., Pullan, A.J. (2006-09-21). Modelling slow wave activity in the small intestine. Journal of Theoretical Biology 242 (2) : 356-362. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jtbi.2006.03.004
Abstract: We have developed an anatomically based model to simulate slow wave activity in the small intestine. Geometric data for the human small intestine were obtained from the Visible Human project. These data were used to create a one-dimensional finite element mesh of the entire small intestine using an iterative fitting procedure. The electrically active components of the intestinal walls were modelled using a modified Fitzhugh-Nagumo cell model embedded within a longitudinal smooth muscle layer and a layer containing Interstitial Cells of Cajal. Within these layers, the monodomain equation was used to describe slow wave propagation. To solve the monodomain equation, a high-resolution finite difference grid, with an average spatial resolution of 0.95 mm, was embedded within each finite element. The resulting simulations of intestinal activity agree with the experimental observation that slow wave frequency gradually declines from 12 cycles per minute (cpm) in the duodenum to 8 cpm at the terminal ileum. Furthermore, the simulations demonstrated a decrease in conduction velocity with distance along the small intestine (10.7 cm/s in the duodenum, 5.1 cm/s in the jejunum and 1.4 cm/s in the ileum), matching experimental recordings from the canine small intestine. We conclude that the framework presented here is capable of qualitatively simulating normal slow wave activity in an anatomical model of the small intestine. © 2006 Elsevier Ltd. All rights reserved.
Source Title: Journal of Theoretical Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/67164
ISSN: 00225193
DOI: 10.1016/j.jtbi.2006.03.004
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

27
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

23
checked on Nov 21, 2017

Page view(s)

24
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.