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Title: Microfluidic devices for blood fractionation
Authors: Hou, H.W.
Bhagat, A.A.S.
Lee, W.C.
Huang, S.
Han, J.
Lim, C.T. 
Keywords: Blood separation
Cell separation
Disease detection and diagnosis
Issue Date: 2011
Citation: Hou, H.W., Bhagat, A.A.S., Lee, W.C., Huang, S., Han, J., Lim, C.T. (2011). Microfluidic devices for blood fractionation. Micromachines 2 (3) : 319-343. ScholarBank@NUS Repository.
Abstract: Blood, a complex biological fluid, comprises 45% cellular components suspended in protein rich plasma. These different hematologic components perform distinct functions in vivo and thus the ability to efficiently fractionate blood into its individual components has innumerable applications in both clinical diagnosis and biological research. Yet, processing blood is not trivial. In the past decade, a flurry of new microfluidic based technologies has emerged to address this compelling problem. Microfluidics is an attractive solution for this application leveraging its numerous advantages to process clinical blood samples. This paper reviews the various microfluidic approaches realized to successfully fractionate one or more blood components. Techniques to separate plasma from hematologic cellular components as well as isolating blood cells of interest including certain rare cells are discussed. Comparisons based on common separation metrics including efficiency (sensitivity), purity (selectivity), and throughput will be presented. Finally, we will provide insights into the challenges associated with blood-based separation systems towards realizing true point-of-care (POC) devices and provide future perspectives. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
Source Title: Micromachines
ISSN: 2072666X
DOI: 10.3390/mi2030319
Appears in Collections:Staff Publications

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