Please use this identifier to cite or link to this item:
|Title:||Microfluidic devices for blood fractionation|
Disease detection and diagnosis
|Source:||Hou, H.W., Bhagat, A.A.S., Lee, W.C., Huang, S., Han, J., Lim, C.T. (2011). Microfluidic devices for blood fractionation. Micromachines 2 (3) : 319-343. ScholarBank@NUS Repository. https://doi.org/10.3390/mi2030319|
|Abstract:||Blood, a complex biological fluid, comprises 45% cellular components suspended in protein rich plasma. These different hematologic components perform distinct functions in vivo and thus the ability to efficiently fractionate blood into its individual components has innumerable applications in both clinical diagnosis and biological research. Yet, processing blood is not trivial. In the past decade, a flurry of new microfluidic based technologies has emerged to address this compelling problem. Microfluidics is an attractive solution for this application leveraging its numerous advantages to process clinical blood samples. This paper reviews the various microfluidic approaches realized to successfully fractionate one or more blood components. Techniques to separate plasma from hematologic cellular components as well as isolating blood cells of interest including certain rare cells are discussed. Comparisons based on common separation metrics including efficiency (sensitivity), purity (selectivity), and throughput will be presented. Finally, we will provide insights into the challenges associated with blood-based separation systems towards realizing true point-of-care (POC) devices and provide future perspectives. © 2011 by the authors; licensee MDPI, Basel, Switzerland.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 6, 2017
WEB OF SCIENCETM
checked on Nov 21, 2017
checked on Dec 10, 2017
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.