Please use this identifier to cite or link to this item: https://doi.org/10.1364/OL.33.000602
Title: Interferometric polarization coherent anti-Stokes Raman scattering (IP-CARS) microscopy
Authors: Lu, F. 
Wei, Z. 
Sheppard, C. 
Zhiwei, H. 
Issue Date: 15-Mar-2008
Source: Lu, F., Wei, Z., Sheppard, C., Zhiwei, H. (2008-03-15). Interferometric polarization coherent anti-Stokes Raman scattering (IP-CARS) microscopy. Optics Letters 33 (6) : 602-604. ScholarBank@NUS Repository. https://doi.org/10.1364/OL.33.000602
Abstract: We report a novel interferometry-based polarization coherent anti-Stokes Raman scattering (IP-CARS) implementation for effectively suppressing the nonresonant background while significantly amplifying the resonant signal for vibrational imaging. By modulating the phase difference between the two interference CARS signals generated from the same sample and measuring the peak-to-peak intensity of the periodically modulated interference CARS signal, the IP-CARS technique yields a sixfold improvement in the signal-tobackground ratio compared with conventional CARS while providing an approximately 20-fold amplification of the resonant CARS signal compared with conventional polarization CARS. We demonstrate this method by imaging 4.69 μm polystyrene beads and unstained human epithelial cells immersed in water. © 2008 Optical Society of America.
Source Title: Optics Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/67123
ISSN: 01469592
DOI: 10.1364/OL.33.000602
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