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|Title:||In vitro and in vivo analysis of co-electrospun scaffolds made of medical grade poly(ε-caprolactone) and porcine collagen|
Smooth muscle cells
|Citation:||Chen, Z.C.C.,Ekaputra, A.K.,Gauthaman, K.,Adaikan, P.G.,Yu, H.,Hutmacher, D.W. (2008-05-01). In vitro and in vivo analysis of co-electrospun scaffolds made of medical grade poly(ε-caprolactone) and porcine collagen. Journal of Biomaterials Science, Polymer Edition 19 (5) : 693-707. ScholarBank@NUS Repository. https://doi.org/10.1163/156856208784089580|
|Abstract:||In this study, a nanofiber mesh made by co-electrospinning medical grade poly(ε-caprolactone) and collagen (mPCL/Col) was fabricated and studied. Its mechanical properties and characteristics were analyzed and compared to mPCL meshes. mPCL/Col meshes showed a reduction in strength but an increase in ductility when compared to PCL meshes. In vitro assays revealed that mPCL/Col supported the attachment and proliferation of smooth muscle cells on both sides of the mesh. In vivo studies in the corpus cavernosa of rabbits revealed that the mPCL/Col scaffold used in conjunction with autologous smooth muscle cells resulted in better integration with host tissue when compared to cell free scaffolds. On a cellular level preseeded scaffolds showed a minimized foreign body reaction. © 2008 VSP.|
|Source Title:||Journal of Biomaterials Science, Polymer Edition|
|Appears in Collections:||Staff Publications|
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