Please use this identifier to cite or link to this item: https://doi.org/10.1364/OE.16.018764
Title: Focal modulation microscopy
Authors: Chen, N. 
Wong, C.-H.
Sheppard, C.J.R. 
Issue Date: 10-Nov-2008
Source: Chen, N., Wong, C.-H., Sheppard, C.J.R. (2008-11-10). Focal modulation microscopy. Optics Express 16 (23) : 18764-18769. ScholarBank@NUS Repository. https://doi.org/10.1364/OE.16.018764
Abstract: We report a novel light microscopy method for high resolution molecular imaging of thick biological tissues with one photon excited fluorescence. Effective optical sectioning and diffraction limited spatial resolution are achieved when imaging deep inside a multiple-scattering medium by the use of focal modulation, a technique for suppressing the background fluorescence signal excited by scattered light. Our method has been validated with animal tissue and an imaging depth around 600 microns has been demonstrated. © 2008 Optical Society of America.
Source Title: Optics Express
URI: http://scholarbank.nus.edu.sg/handle/10635/67065
ISSN: 10944087
DOI: 10.1364/OE.16.018764
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