Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.b.30952
Title: Extruded collagen-polyethylene glycol fibers for tissue engineering applications
Authors: Zeugolis, D.I. 
Paul, R.G.
Attenburrow, G.
Keywords: Biomimetic
Collagen
Scaffolds
Tissue engineering
Issue Date: May-2008
Citation: Zeugolis, D.I., Paul, R.G., Attenburrow, G. (2008-05). Extruded collagen-polyethylene glycol fibers for tissue engineering applications. Journal of Biomedical Materials Research - Part B Applied Biomaterials 85 (2) : 343-352. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.b.30952
Abstract: The repair of anterior cruciate ligament, skin, tendon and cartilage remains a challenging clinical problem. Extruded collagen fibers comprise a promising scaffold for tissue engineering applications; however the engineering of these fibers has still to be improved to bring this material to clinical practice. Herein we investigate the influence of collagen concentration, the amount of PEG Mw 8K and the extrusion tube internal diameter on the properties of these fibers. Ultrastructural evaluation revealed packed intra-fibrillar structure. The thermal properties were found to be independent of the collagen concentration, the amount of PEG or the extrusion tube internal diameter (p > 0.05). An inversely proportional relationship between dry fiber diameter and stress at break was found. The 20% PEG was identified as the optimal amount required for the production of reproducible fibers. Increasing the collagen concentration resulted in fibers with higher diameter (p < 0.001), force (p < 0.001) and strain at break (p < 0.02) values, whilst the stress at break (p < 0.001) and the modulus (p < 0.007) values were decreased. Increasing the extrusion tube internal diameter influence significantly (p < 0.001) all the investigated mechanical properties. Overall, extruded collagen fibers were produced with properties similar to those of native or synthetic fibers to suit a wide range of tissue engineering applications. © 2007 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part B Applied Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/67049
ISSN: 15524973
DOI: 10.1002/jbm.b.30952
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

44
checked on Jul 14, 2018

WEB OF SCIENCETM
Citations

38
checked on Jun 19, 2018

Page view(s)

37
checked on Feb 25, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.