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https://scholarbank.nus.edu.sg/handle/10635/67043
DC Field | Value | |
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dc.title | Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo. | |
dc.contributor.author | Lam, C.X. | |
dc.contributor.author | Hutmacher, D.W. | |
dc.contributor.author | Schantz, J.T. | |
dc.contributor.author | Woodruff, M.A. | |
dc.contributor.author | Teoh, S.H. | |
dc.date.accessioned | 2014-06-17T09:43:45Z | |
dc.date.available | 2014-06-17T09:43:45Z | |
dc.date.issued | 2009-09-01 | |
dc.identifier.citation | Lam, C.X.,Hutmacher, D.W.,Schantz, J.T.,Woodruff, M.A.,Teoh, S.H. (2009-09-01). Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo.. Journal of biomedical materials research. Part A 90 (3) : 906-919. ScholarBank@NUS Repository. | |
dc.identifier.issn | 15524965 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/67043 | |
dc.description.abstract | The use of polycaprolactone (PCL) as a biomaterial, especially in the fields of drug delivery and tissue engineering, has enjoyed significant growth. Understanding how such a device or scaffold eventually degrades in vivo is paramount as the defect site regenerates and remodels. Degradation studies of three-dimensional PCL and PCL-based composite scaffolds were conducted in vitro (in phosphate buffered saline) and in vivo (rabbit model). Results up to 6 months are reported. All samples recorded virtually no molecular weight changes after 6 months, with a maximum mass loss of only about 7% from the PCL-composite scaffolds degraded in vivo, and a minimum of 1% from PCL scaffolds. Overall, crystallinity increased slightly because of the effects of polymer recrystallization. This was also a contributory factor for the observed stiffness increment in some of the samples, while only the PCL-composite scaffold registered a decrease. Histological examination of the in vivo samples revealed good biocompatibility, with no adverse host tissue reactions up to 6 months. Preliminary results of medical-grade PCL scaffolds, which were implanted for 2 years in a critical-sized rabbit calvarial defect site, are also reported here and support our scaffold design goal for gradual and late molecular weight decreases combined with excellent long-term biocompatibility and bone regeneration. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | BIOENGINEERING | |
dc.description.sourcetitle | Journal of biomedical materials research. Part A | |
dc.description.volume | 90 | |
dc.description.issue | 3 | |
dc.description.page | 906-919 | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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