Please use this identifier to cite or link to this item: https://doi.org/10.1021/bm3005879
Title: Encapsulation of basic fibroblast growth factor by polyelectrolyte multilayer microcapsules and its controlled release for enhancing cell proliferation
Authors: She, Z.
Wang, C.
Li, J. 
Sukhorukov, G.B.
Antipina, M.N.
Issue Date: 9-Jul-2012
Source: She, Z., Wang, C., Li, J., Sukhorukov, G.B., Antipina, M.N. (2012-07-09). Encapsulation of basic fibroblast growth factor by polyelectrolyte multilayer microcapsules and its controlled release for enhancing cell proliferation. Biomacromolecules 13 (7) : 2174-2180. ScholarBank@NUS Repository. https://doi.org/10.1021/bm3005879
Abstract: (Graph Presented) Basic fibroblast growth factor (FGF2) is an important protein for cellular activity and highly vulnerable to environmental conditions. FGF2 protected by heparin and bovine serum albumin was loaded into the microcapsules by a coprecipitation-based layer-by-layer encapsulation method. Low cytotoxic and biodegradable polyelectrolytes dextran sulfate and poly-l-arginine were used for capsule shell assembly. The shell thickness-dependent encapsulation efficiency was measured by enzyme-linked immunosorbent assay. A maximum encapsulation efficiency of 42% could be achieved by microcapsules with a shell thickness of 14 layers. The effects of microcapsule concentration and shell thickness on cytotoxicity, FGF2 release kinetics, and L929 cell proliferation were evaluated in vitro. The advantage of using microcapsules as the carrier for FGF2 controlled release for enhancing L929 cell proliferation was analyzed (Graph Presented). © 2012 American Chemical Society.
Source Title: Biomacromolecules
URI: http://scholarbank.nus.edu.sg/handle/10635/67030
ISSN: 15257797
DOI: 10.1021/bm3005879
Appears in Collections:Staff Publications

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