Please use this identifier to cite or link to this item: https://doi.org/10.1364/OL.38.002321
Title: Development of a beveled fiber-optic confocal Rama probe for enhancing in vivo epithelia tissue Raman measurements at endoscopy
Authors: Wang, J.
Bergholt, M.S. 
Zheng, W. 
Huang, Z. 
Issue Date: 1-Jul-2013
Source: Wang, J., Bergholt, M.S., Zheng, W., Huang, Z. (2013-07-01). Development of a beveled fiber-optic confocal Rama probe for enhancing in vivo epithelia tissue Raman measurements at endoscopy. Optics Letters 38 (13) : 2321-2323. ScholarBank@NUS Repository. https://doi.org/10.1364/OL.38.002321
Abstract: We reporton the developmentofabeveled fiber-optic confocal Raman probe coupled with a ball lens for enhancing in vivo epithelial tissue Raman measurements at endoscopy. Our Monte Carlo simulations show that by selecting a proper fiber-ball lens distance and beveled angle of collection fibers, the confocal Raman probe design can be optimized for maximizing shallower tissue Raman measurements in epithelial tissue; in addition, the ratio of epithelium to stromal Raman photons collected using an optimized confocal Raman probe is approximately 19-fold higher than that usingavolume-type Raman probe. Further experiments confirm that the confocal Raman endoscopic probe developed is in favor of probing superficial tissue Raman signals from a two-layer tissue phantom as well as esophagus tissue in vivo during endoscopy. This work suggests the great potential of applying the beveled fiber-optic confocal Raman probe for improving in vivo diagnosis of precancer occurring in epithelial tissue at endoscopy. © 2013 Optical Society of America.
Source Title: Optics Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/67001
ISSN: 01469592
DOI: 10.1364/OL.38.002321
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

34
checked on Jan 16, 2018

WEB OF SCIENCETM
Citations

31
checked on Jan 16, 2018

Page view(s)

54
checked on Jan 13, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.