Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201100191
Title: Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery
Authors: Bao, H.
Pan, Y.
Ping, Y.
Sahoo, N.G.
Wu, T.
Li, L.
Li, J. 
Gan, L.H.
Keywords: chitosan
drug delivery
gene delivery
graphene oxide
nanocarriers
Issue Date: 6-Jun-2011
Source: Bao, H., Pan, Y., Ping, Y., Sahoo, N.G., Wu, T., Li, L., Li, J., Gan, L.H. (2011-06-06). Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery. Small 7 (11) : 1569-1578. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201100191
Abstract: The covalent functionalization of graphene oxide (GO) with chitosan (CS) is successfully accomplished via a facile amidation process. The CS-grafted GO (GO-CS) sheets consist of about 64 wt.% CS, which imparts them with a good aqueous solubility and biocompatibility. Additionally, the physicochemical properties of GO-CS are studied. As a novel nanocarrier, GO-CS is applied to load a water-insoluble anticancer drug, camptothecin (CPT), via π-π stacking and hydrophobic interactions. It is demonstrated that GO-CS possesses a superior loading capacity for CPT, and the GO-CS-CPT complexes show remarkably high cytotoxicity in HepG2 and HeLa cell lines compared to the pure drug. At the same time, GO-CS is also able to condense plasmid DNA into stable, nanosized complexes, and the resulting GO-CS/pDNA nanoparticles exhibit reasonable transfection efficiency in HeLa cells at certain nitrogen/phosphate ratios. Therefore, the GO-CS nanocarrier is able to load and deliver both anticancer drugs and genes. The covalent functionalization of graphene oxide (GO) with chitosan (CS) is accomplished via a facile method. It is demonstrated that GO-CS possesses a superior loading capacity for camptothecin (CPT), and the GO-CS-CPT complexes show remarkably high cytotoxicity in cancer cells. In addition, GO-CS is able to transport plasmid DNA into HeLa cells with a reasonable transfection efficiency. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Small
URI: http://scholarbank.nus.edu.sg/handle/10635/66963
ISSN: 16136810
DOI: 10.1002/smll.201100191
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

380
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

356
checked on Nov 21, 2017

Page view(s)

56
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.