Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.a.31976
Title: Cationic supramolecules consisting of oligoethylenimine-grafted α-cyclodextrins threaded on poly(ethylene oxide) for gene delivery
Authors: Yang, C. 
Li, H.
Wang, X.
Li, J. 
Keywords: Cationic polymer
Cyclodextrin
Gene delivery
Polyethylenimine
Supramolecule
Issue Date: Apr-2009
Source: Yang, C., Li, H., Wang, X., Li, J. (2009-04). Cationic supramolecules consisting of oligoethylenimine-grafted α-cyclodextrins threaded on poly(ethylene oxide) for gene delivery. Journal of Biomedical Materials Research - Part A 89 (1) : 13-23. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.31976
Abstract: In this study, three cationic polyrotaxanes composed of multiple oligoethylenimine-grafted α-cyclo-dextrin rings threaded on a poly(ethylene oxide) chain have been synthesized and characterized, and investigated for gene delivery. All three cationic polyrotaxanes could efficiently compact pDNA into small nanoparticles, with diameters ranging from 100 to 200 nm. In both BHK-21 and MES-SA cell lines, the transfection efficiency mediated by the cationic polyrotaxanes were comparable or even higher than that of branched polyethylenimine (PEI) with a molecular weight of 25 kDa, which is one of the most efficient gene-delivery vectors to date. Moreover, the cationic polyrotaxanes showed much lower cytotoxicity than branched PEI (25 kDa). Hence, these cationic poly rotaxanes have high potentials as new carriers for gene delivery. © 2008 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part A
URI: http://scholarbank.nus.edu.sg/handle/10635/66954
ISSN: 15493296
DOI: 10.1002/jbm.a.31976
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