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|Title:||Beveled fiber-optic probe couples a ball lens for improving depth-resolved fluorescence measurements of layered tissue: Monte Carlo simulations|
|Authors:||Jaillon, F. |
|Source:||Jaillon, F.,Zheng, W.,Huang, Z. (2008). Beveled fiber-optic probe couples a ball lens for improving depth-resolved fluorescence measurements of layered tissue: Monte Carlo simulations. Physics in Medicine and Biology 53 (4) : 937-951. ScholarBank@NUS Repository. https://doi.org/4/008|
|Abstract:||In this study, we evaluate the feasibility of designing a beveled fiber-optic probe coupled with a ball lens for improving depth-resolved fluorescence measurements of epithelial tissue using Monte Carlo (MC) simulations. The results show that by using the probe configuration with a beveled tip collection fiber and a flat tip excitation fiber associated with a ball lens, discrimination of fluorescence signals generated in different tissue depths is achievable. In comparison with a flat-tip collection fiber, the use of a large bevel angled collection fiber enables a better differentiation between the shallow and deep tissue layers by changing the excitation-collection fiber separations. This work suggests that the beveled fiber-optic probe coupled with a ball lens has the potential to facilitate depth-resolved fluorescence measurements of epithelial tissues. © 2008 Institute of Physics and Engineering in Medicine.|
|Source Title:||Physics in Medicine and Biology|
|Appears in Collections:||Staff Publications|
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