Please use this identifier to cite or link to this item:
https://doi.org/10.2147/CIA.S32513
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dc.title | Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time | |
dc.contributor.author | Lee, J.H. | |
dc.contributor.author | Chun, K.J. | |
dc.contributor.author | Kim, H.S. | |
dc.contributor.author | Kim, S.H. | |
dc.contributor.author | Han, P. | |
dc.contributor.author | Jun, Y. | |
dc.contributor.author | Lim, D. | |
dc.date.accessioned | 2014-06-17T09:42:08Z | |
dc.date.available | 2014-06-17T09:42:08Z | |
dc.date.issued | 2012-08-09 | |
dc.identifier.citation | Lee, J.H., Chun, K.J., Kim, H.S., Kim, S.H., Han, P., Jun, Y., Lim, D. (2012-08-09). Alteration patterns of trabecular bone microarchitectural characteristics induced by osteoarthritis over time. Clinical Interventions in Aging 7 : 303-312. ScholarBank@NUS Repository. https://doi.org/10.2147/CIA.S32513 | |
dc.identifier.issn | 11769092 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/66911 | |
dc.description.abstract | Information regarding the alteration of trabecular bone microarchitecture, which is one of the important criteria to estimate bone condition, induced by osteoarthritis (OA) is sparse. The current study therefore aimed to identify and quantify patterns of alterations in trabecular bone microarchitectural characteristics at tibial epiphysis induced by OA using in vivo microcomputed tomography. Fourteen 8-week-old female Sprague Dawley rats were randomly divided into control (n = 7) and OA (n = 7) groups. Rats in the OA group were administered monoiodoacetate into the knee-joint cavity. The tibial joints were scanned by in vivo microcomputed tomography at 0, 4, and 8 weeks after administration. Two-way analysis of variance with Tukey's honestly significant difference post hoc test was carried out for statistical analyses. The results showed that patterns of alterations in the trabecular bone microarchitectural characteristics in the OA group were not different from those in the control group from 0 to 4 weeks (P > 0.05), but differed from 4 to 8 weeks (P < 0.05). In particular, both trabecular bone thickness and trabecular bone separation distributions over time (4-8 weeks) differed significantly (P < 0.05). These findings suggest that the patterns of bone microarchitecture changes brought about by OA should be periodically considered in the diagnosis and management of arthritic symptoms over time. Improved understanding of the alteration pattern on trabecular bone microarchitecture may assist in developing more targeted treatment interventions for OA. © 2012 Lee et al. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2147/CIA.S32513 | |
dc.source | Scopus | |
dc.subject | In vivo microcomputed tomography | |
dc.subject | Osteoarthritis | |
dc.subject | Trabecular bone microarchitectural characteristics | |
dc.subject | Trabecular bone separation distribution | |
dc.subject | Trabecular bone thickness distribution | |
dc.type | Article | |
dc.contributor.department | BIOENGINEERING | |
dc.description.doi | 10.2147/CIA.S32513 | |
dc.description.sourcetitle | Clinical Interventions in Aging | |
dc.description.volume | 7 | |
dc.description.page | 303-312 | |
dc.identifier.isiut | 000307375200001 | |
Appears in Collections: | Staff Publications Elements |
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2012-alteration_patterns_trabecular_bone_microarchitectural-pub.pdf | 2.02 MB | Adobe PDF | OPEN | Published | View/Download |
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