Please use this identifier to cite or link to this item: https://doi.org/10.1007/BF02492468
Title: The theoretical study of the effect of packing heterogeneity on HPLC by computational fluid dynamics
Authors: Wu, Y.X.
Ching, C.B. 
Keywords: Column liquid chromatography
Computational fluid dynamics
Heterogeneous packing
Issue Date: Dec-2002
Source: Wu, Y.X., Ching, C.B. (2002-12). The theoretical study of the effect of packing heterogeneity on HPLC by computational fluid dynamics. Chromatographia 56 (11-12) : 679-686. ScholarBank@NUS Repository. https://doi.org/10.1007/BF02492468
Abstract: Based on the assumption of a radial parabolic porosity distribution across a chromatographic column and an ideal distribution and collection system for the column, a theoretical study of the effect of heterogeneous packing on the behavior of chromatography was conducted using Computational Fluid Dynamics (CFD) simulation. This study examined the development of the velocity distribution in columns with different porosity variations and different diameters, visualized the effect of velocity distribution on concentration profiles inside the column and the eluted pulses at the exit and finally the column efficiency. Therefore, this study is helpful to enhance the understanding to the effect of packing quality on chromatography. The final result suggests that packing heterogeneity in current widely used chromatographic columns might seriously impair the separation efficiency of the columns.
Source Title: Chromatographia
URI: http://scholarbank.nus.edu.sg/handle/10635/66873
ISSN: 00095893
DOI: 10.1007/BF02492468
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

9
checked on Dec 5, 2017

WEB OF SCIENCETM
Citations

9
checked on Dec 5, 2017

Page view(s)

23
checked on Dec 11, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.