Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0021-9673(02)00043-2
Title: Synthesis and chromatographic properties of a novel chiral stationary phase derived from heptakis(6-azido-6-deoxy-2,3-di-O-phenylcarbamoylated)-β-cyclodextrin immobilized onto amino-functionalized silica gel via multiple urea linkages
Authors: Chen, L.
Zhang, L.-F.
Ching, C.-B. 
Ng, S.-C. 
Keywords: Chiral stationary phases, LC
Enantiomer separation
Issue Date: 15-Mar-2002
Source: Chen, L.,Zhang, L.-F.,Ching, C.-B.,Ng, S.-C. (2002-03-15). Synthesis and chromatographic properties of a novel chiral stationary phase derived from heptakis(6-azido-6-deoxy-2,3-di-O-phenylcarbamoylated)-β-cyclodextrin immobilized onto amino-functionalized silica gel via multiple urea linkages. Journal of Chromatography A 950 (1-2) : 65-74. ScholarBank@NUS Repository. https://doi.org/10.1016/S0021-9673(02)00043-2
Abstract: A novel chiral stationary phase (PPHCDN7) was prepared by immobilization of heptakis(6-azido-6-deoxy-2,3-di-O-phenylcarbamoylated)-β-cyclodextrin (PPHCD) onto the surface of amino-functionalized silica gel via multiple urea linkages derived from an extended application of the Staudinger reaction. A wide range of structurally divergent racemic drugs and other compounds were successfully separated into their enantiomers under both normal and reversed-phase conditions. β-Adrenergic blockers and racemic tertiary, secondary and primary amines were readily separated using a mixture of methanol and aqueous triethylammonium acetate buffer. The optimal pH value for the separation falls in the range of 4.65 to 6.30. With atropine and isoproterenol, good enantioseparations with separation factors of α<5 were easily attainable. © 2002 Elsevier Science B.V.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/66859
ISSN: 00219673
DOI: 10.1016/S0021-9673(02)00043-2
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