Please use this identifier to cite or link to this item:
|Title:||Study of feed temperature control of chromatography using computional fluid dynamics simulation|
|Authors:||Ching, C.B. |
|Keywords:||Computational fluid dynamics|
|Source:||Ching, C.B., Wu, Y.X., Lisso, M., Wozny, G., Laiblin, T., Arlt, W. (2002-02-01). Study of feed temperature control of chromatography using computional fluid dynamics simulation. Journal of Chromatography A 945 (1-2) : 117-131. ScholarBank@NUS Repository. https://doi.org/10.1016/S0021-9673(01)01479-0|
|Abstract:||Recently preparative high-performance liquid chromatography (HPLC) has been used more and more frequently to separate drugs and natural substances. However, large-scale HPLC easily tends to reduce the yield and purity of the product. Hydrodynamic and heat factors play an important roles. Generally, in a large-scale HPLC column, the tracer profile inside column will take on a parabolic shape because of the distributor, which will impact the separation performance of the column. With the inlet temperature suitably lower than the wall temperature, this situation could be improved to some extent. In this work, some experiments were conducted using HPLC, with a column 10 cm in diameter to determine the optimal temperature difference between wall and inlet temperatures. The wall temperature was fixed at about 30 °C and the inlet temperature varied from 15 to 30 °C. The flow-rate of the eluent, methanol, was 300 ml/min. The experimental result was simulated using CFD software FLUENT 4.4.4. The simulated temperature field fitted the experimental one very well and the simulated flow, temperature and tracer distribution inside column could provide good explanation of separation performance under different conditions. In addition, the simulation could at least approximately predict the optimal temperature difference. © 2002 Elsevier Science B.V. All rights reserved.|
|Source Title:||Journal of Chromatography A|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 14, 2018
WEB OF SCIENCETM
checked on Jan 22, 2018
checked on Feb 19, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.